Embedded Files
We study how mitochondria and their network of interacting pathways shape complex disease phenotypes such as inflammation and neurodegeneration using chemical genetics and systems-level analysis.
Complex Diseases and Mitochondria
Complex Diseases and Mitochondria
Understanding how mitochondrial dysfunction leads to complex disease phenotypes
Chemical Genetics Approach
Chemical Genetics Approach
Discovering pathways that modify mitochondrial homeostasis and cellular stress responses
Drug and Nanoparticle Toxicity
Drug and Nanoparticle Toxicity
Uncovering how chemicals and nanoparticles induce mitochondrial and cellular toxicity
Selected Publications
• Tran UT & Kitami T. 2024. Journal of Nanobiotechnology.
By using our multi-matrixed chemical screening strategy, we dissected the mechanism by which nanoparticles induce inflmammatory response in macrophage.
• Tran UT & Kitami T. 2019. Communications Biology.
This was our first attempt in appliying chemical screens to understand the role of mitochondria in inflammatory pathway.
• Kitami T, Logan DJ, Negri J, Hasaka T, Tolliday NJ, Carpenter AE, Spiegelman BM, Mootha VK. 2012. PLoS ONE.
Through 30,000 compound screening, we re-discovered 1977 finding (Pasakony et al.) that mitochondrial content scales with cell size.
• Wagner BK*, Kitami T* (co-first), Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, Golub TR, Mootha VK. 2008. Nature Biotechnology.
By taking advantage of the differences in various mitochondrial readouts, we uncovered new mitochondrial drug toxicity, drug target, and scaling properties of mitochondria through data-mining.
We welcome collaborators interested in mitochondrial biology, disease mechanisms, chemical screening, and systems-level approaches.
Page updated
Google Sites
Report abuse